Evolutionarily Conserved Requirement for Core Binding Factor Beta in the Assembly of the Human Immunodeficiency Virus/Simian Immunodeficiency Virus Vif-Cullin 5-RING E3 Ubiquitin Ligase

被引：25
|
作者：
Han, Xue [1 ,3 ,4 ]
Liang, Weizi [1 ]
Hua, Deping [1 ]
Zhou, Xiaohong [2 ,3 ]
Du, Juan [2 ]
Evans, Sean L. [3 ]
Gao, Qimeng [3 ]
Wang, Hong [2 ]
Viqueira, Rachel [5 ]
Wei, Wei [1 ,3 ]
Zhang, Wenyan [2 ]
Yu, Xiao-Fang [1 ,3 ,4 ]
机构：
[1] Tianjin Univ, Sch Life Sci, Tianjin 300072, Peoples R China
[2] Jilin Univ, Hosp 1, Inst Virol & AIDS Res, Changchun 130023, Jilin Province, Peoples R China
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA
[4] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China
[5] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA
来源：
JOURNAL OF VIROLOGY | 2014年 / 88卷 / 06期
关键词：
VIRAL INFECTIVITY FACTOR; HIV-1; VIF; TYPE-1; CBF-BETA; APOBEC3G DEGRADATION; RESTRICTION FACTORS; DEAMINASE APOBEC3G; CYTIDINE DEAMINASE; ANTIVIRAL ACTIVITY; HOST RESTRICTION;
D O I：
10.1128/JVI.03833-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The human immunodeficiency virus type 1 (HIV-1)-encoded virion infectivity factor (Vif) is required to inactivate the host restriction factor APOBEC3 by engaging Cullin 5 (Cul5)-RING ubiquitin ligase (CRL5). Core binding factor beta (CBE-beta) is a novel regulator of Vif-CRL5 function; as yet, its mechanism of regulation remains unclear. In the present study, we demonstrate that CBF-beta promotion of Vif-CRL5 assembly is independent of its influence on Vif stability and is also a conserved feature of primate lentiviral Vif proteins. Furthermore, CBF-beta is critical for the formation of the Vif-ElonginB/ElonginC-Cul5 core E3 ubiquitin ligase complex in vitro. CBF-beta from diverse vertebrate species supported HIV-1 Vif function, indicating the conserved nature of Vif CBF-beta interfaces. Considering the importance of the interaction between Vif and CBF-beta in viral CRL5 function, disrupting this interaction represents an attractive pharmacological intervention against HIV-1.
引用
收藏
页码：3320 / 3328
页数：9
相关论文
共 14 条
  • [1] Core Binding Factor Beta Plays a Critical Role by Facilitating the Assembly of the Vif-Cullin 5 E3 Ubiquitin Ligase
    Fribourgh, Jennifer L.
    Nguyen, Henry C.
    Wolfe, Leslie S.
    DeWitt, David C.
    Zhang, Wenyan
    Yu, Xiao-Fang
    Rhoades, Elizabeth
    Xiong, Yong
    JOURNAL OF VIROLOGY, 2014, 88 (06) : 3309 - 3319
  • [2] Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly
    Stanley, Bradford J.
    Ehrlich, Elana S.
    Short, Leslie
    Yu, Yunkai
    Xiao, Zuoxiang
    Yu, Xiao-Fang
    Xiong, Yong
    JOURNAL OF VIROLOGY, 2008, 82 (17) : 8656 - 8663
  • [3] Regulation of Apobec3F and human immunodeficiency virus type 1 Vif by Vif-Cul5-ElonB/C E3 ubiquitin ligase
    Liu, BD
    Sarkis, PTN
    Luo, K
    Yu, YK
    Yu, XF
    JOURNAL OF VIROLOGY, 2005, 79 (15) : 9579 - 9587
  • [4] Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen
    Hartmann, Thomas
    Xu, Xinsong
    Kronast, Mira
    Muehlich, Susanne
    Meyer, Kathleen
    Zimmermann, Wolfgang
    Hurwitz, Jerard
    Pan, Zhen-Qiang
    Engelhardt, Stefan
    Sarikas, Antonio
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (09) : 3371 - 3376
  • [5] Inhibition of Cullin-RING E3 ubiquitin ligase 7 by Simian virus 40 large T-antigen
    Hartmann, T.
    Engelhardt, S.
    Sarikas, A.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2013, 386 : S69 - S70
  • [6] Role of TRIM5α RING Domain E3 Ubiquitin Ligase Activity in Capsid Disassembly, Reverse Transcription Blockade, and Restriction of Simian Immunodeficiency Virus
    Kim, Jonghwa
    Tipper, Christopher
    Sodroski, Joseph
    JOURNAL OF VIROLOGY, 2011, 85 (16) : 8116 - 8132
  • [7] Core-Binding Factor β Increases the Affinity between Human Cullin 5 and HIV-1 Vif within an E3 Ligase Complex
    Salter, Jason D.
    Lippa, Geoffrey M.
    Belashov, Ivan A.
    Wedekind, Joseph E.
    BIOCHEMISTRY, 2012, 51 (44) : 8702 - 8704
  • [8] Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction
    Duan, Sizhu
    Yu, Xin
    Wang, Chu
    Meng, Lina
    Gai, Yanxin
    Zhou, Yan
    Gu, Tiejun
    Yu, Bin
    Wu, Jiaxin
    Yu, Xianghui
    JOURNAL OF VIROLOGY, 2022, 96 (17)
  • [9] Human immunodeficiency virus type 1 vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation
    DeHart, Jason L.
    Bosque, Alberto
    Harris, Reuben S.
    Planelles, Vicente
    JOURNAL OF VIROLOGY, 2008, 82 (18) : 9265 - 9272
  • [10] Identification of a Cullin5-ElonginB-ElonginC E3 Complex in Degradation of Feline Immunodeficiency Virus Vif-Mediated Feline APOBEC3 Proteins
    Wang, Jiawen
    Zhang, Wenyan
    Lv, Mingyu
    Zuo, Tao
    Kong, Wei
    Yu, Xianghui
    JOURNAL OF VIROLOGY, 2011, 85 (23) : 12482 - 12491
12