Synthesis of chiral sultams with two adjacent stereocenters via palladium-catalyzed dynamic kinetic resolution

被引：15
|
作者：
Song, Bo [1 ]
Chen, Mu-Wang [1 ]
Zhou, Yong-Gui [1 ,2 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 07期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC REDUCTIVE AMINATION; BORROWING HYDROGEN METHODOLOGY; ALPHA-KETO ESTERS; N-H IMINES; ENANTIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; SECONDARY ALCOHOLS; ALIPHATIC-KETONES; AROMATIC KETONES; METAL-CATALYSTS;
D O I：
10.1039/c7qo01098b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed intramolecular asymmetric reductive amination of racemic -branched ketones bearing the poorly nucleophilic sulfonamides has been successfully developed through dynamic kinetic resolution, providing chiral -sultams with two contiguous stereogenic centers with high diastereoselectivity and enantioselectivity.
引用
收藏
页码：1113 / 1117
页数：5
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