One-pot Three-component Synthesis of Spiro[pyrazolo[3,4-b]pyridine-4,3′-indoline] Derivatives Catalyzed by Melamine Trisulfonic Acid

被引：6
|
作者：
Yang, Li-Min [1 ]
Sun, Peng-Li [1 ]
Wu, Li-Qiang [1 ]
机构：
[1] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2012年 / 59卷 / 12期
关键词：
Spiro[pyrazolo[3,4-b]pyridine-4,3 '-indoline; Melamine trisulfonic acid; Catalysis; Green chemistry; ALDEHYDES; EFFICIENT; AMINES;
D O I：
10.1002/jccs.201200046
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel spiro[pyrazolo[3,4-b]pyridine-4,3'-indoline] derivatives were prepared by the three-component reaction of isatins 3-methyl-1-phenyl-1H-pyrazol-5-amine and Meldrum's acid in the presence of a catalytic amount of melamine trisulfonic acid. This protocol provides a simple one-step procedure with the advantages of easy work-up, mild reaction conditions and environmentally benign.
引用
收藏
页码：1500 / 1503
页数：4
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