Directed evolution of gold nanoparticle delivery to cells

被引：89
|
作者：
Li, Na [1 ]
Larson, Timothy [2 ]
Nguyen, Hong H. [1 ]
Sokolov, Konstantin V. [2 ]
Ellington, Andrew D. [1 ]
机构：
[1] Univ Texas Austin, Inst Cell & Mol Biol, Dept Chem & Biochem, Austin, TX 78712 USA
[2] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 03期
基金：
美国国家卫生研究院;
关键词：
EPIDERMAL GROWTH-FACTOR; GENE-REGULATION; RECEPTOR; APTAMER; INTERNALIZATION;
D O I：
10.1039/b920865h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A newly selected anti-receptor (anti-EGFR) aptamer was conjugated to gold nanoparticles via a facile hybridization method and was found to specifically and quantitatively direct the delivery of gold nanoparticles to cells expressing EGFR through receptor-mediated endocytosis.
引用
收藏
页码：392 / 394
页数：3
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