Gold/Polyoxometalate Core/Shell Nanoparticles for Combined Chemotherapy-Photothermal Cancer Therapy

被引：20
|
作者：
Tomane, Somia [1 ,2 ]
Wilhelm, Claire [3 ,4 ]
Boujday, Souhir [2 ]
Fromain, Alexandre [3 ,4 ]
Miche, Antoine [2 ]
Bourdreux, Flavien [1 ]
Dolbecq, Anne [1 ]
Mialane, Pierre [1 ]
Vallee, Anne [1 ]
机构：
[1] Univ Paris Saclay, UMR CNRS 8180, UVSQ, Inst Lavoisier Versailles, F-78035 Versailles, France
[2] Sorbonne Univ, CNRS, Lab Reactivite Surface LRS, F-75005 Paris, France
[3] Univ Paris, UMR CNRS 7057, Lab Matiere & Syst Complexes MSC, F-75013 Paris, France
[4] Univ PSL, Sorbonne Univ, CNRS, UMR168,Lab Phys Chim Curie,Inst Curie, F-75005 Paris, France
来源：
ACS APPLIED NANO MATERIALS | 2021年 / 4卷 / 03期
关键词：
core/shell nanoparticles; gold nanoparticles; polyoxometalate; hyperthermia; cancer treatment;
D O I：
10.1021/acsanm.0c03187
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We designed monodisperse and perfectly shaped core/shell AuNP@Mo(4)Zol(2)Mn nanohybrids consisting of gold nanoparticles (AuNPs) functionalized by an antitumoral polyoxometalate (POM) incorporating the biologically active zoledronate ligand. After incubation, the nanoparticles were readily confined in the endosomal compartments of PC3 human prostate adenocarcinoma cells. Under photothermal treatment, the metabolic activity drastically decreased at concentrations where the nanohybrids exhibited no anticancer activity in the dark, and almost all cancer cells were killed at concentrations at which zoledronate alone was totally inactive. This study evidences for the first time that AuNPs capped by POMs can represent excellent candidates for combined chemotherapy and photothermal cancer therapy.
引用
收藏
页码：2339 / 2344
页数：6
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