Putative cancer stem cells in cutaneous malignancies

被引：35
|
作者：
Kamstrup, Maria R. [1 ]
Gniadecki, Robert [1 ]
Skovgaard, Gunhild L. [1 ]
机构：
[1] Univ Copenhagen, Bispebjerg Hosp, Dept Dermatol, DK-2400 Copenhagen, Denmark
来源：
EXPERIMENTAL DERMATOLOGY | 2007年 / 16卷 / 04期
关键词：
cancer; skin; stem cell; CHRONIC MYELOCYTIC-LEUKEMIA; MYCOSIS-FUNGOIDES; MYELOID-LEUKEMIA; SIDE-POPULATION; PROGENITOR CELLS; TUMOR-CELL; LYMPHOMA; IDENTIFICATION; CARCINOMA; HEDGEHOG;
D O I：
10.1111/j.1600-0625.2007.00547.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Recent experimental data offer convincing evidence for the existence of cancer stem cells in leukaemia, brain tumors and breast cancer. These cells are responsible for the maintenance of tumor growth and relapses after cytoreductive treatments. This paper provides a brief overview of current data supporting the idea of cancer stem cells in the pathogenesis of cutaneous malignancies, including skin carcinoma, malignant melanoma and cutaneous T-cell lymphoma. The characterization of putative cancer stem cells is important to develop new therapies selectively targeting these cells.
引用
收藏
页码：297 / 301
页数：5
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