Runx2 deficiency in osteoblasts induces an immunosuppressive bone microenvironment and promotes myeloma metastasis to bone

被引:0
|
作者
Xu, X. [1 ]
Trotter, T. [1 ]
Javed, A. [1 ]
Li, J. [2 ]
Yang, Y. [1 ]
机构
[1] Univ Alabama Birmingham, Birmingham, AL USA
[2] First Affiliated Hosp Sun Yat Sen Univ, Guangzhou, Guangdong, Peoples R China
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
P1653
引用
收藏
页码:1551 / 1551
页数:1
相关论文
共 50 条
  • [1] Runx2 Deficiency in Osteoblasts Promotes Myeloma Progression by Altering the Bone Microenvironment at New Bone Sites
    Xu, Xiaoxuan
    Zhang, Chao
    Trotter, Timothy N.
    Gowda, Pramod S.
    Lu, Yun
    Ponnazhagan, Selvarangan
    Javed, Amjad
    Li, Juan
    Yang, Yang
    CANCER RESEARCH, 2020, 80 (05) : 1036 - 1048
  • [2] Runx2 Deficiency in Osteoblasts Promotes Myeloma Resistance to Bortezomib by Suppressing Immunity in Bone Marrow
    Zhang, Chao
    Trotter, Timothy
    Gowda, Pramod
    Lu, Yun
    Javed, Amjad
    Yang, Yang
    JOURNAL OF BONE AND MINERAL RESEARCH, 2022, 37 : 333 - 333
  • [3] Runx2 Deficiency in Committed Osteoblasts Promotes Myeloma Cell Homing to and Progression in New Bone Sites
    Xu, Xiaoxuan
    Li, Juan
    Trotter, Timothy
    Gowda, Pramod
    Hao, Xiaoxiao
    Calahan, Jacob
    Innis-Shelton, Racquel
    Javed, Amjad
    Yang, Yang
    BLOOD, 2017, 130
  • [4] Myeloma cell-derived Runx2 promotes myeloma progression in bone
    Trotter, Timothy N.
    Li, Mei
    Pan, Qianying
    Peker, Deniz
    Rowan, Patrick D.
    Li, Juan
    Zhan, Fenghuang
    Suva, Larry J.
    Javed, Amjad
    Yang, Yang
    BLOOD, 2015, 125 (23) : 3598 - 3608
  • [5] Osteocyte apoptosis induces an immunosuppressive microenvironment in bone marrow and promotes myeloma chemoresistance
    Hao, Xiaoxiao
    Zhang, Chao
    Trotter, Timothy N.
    Gowda, Pramod S.
    Yang, Yang
    CANCER IMMUNOLOGY RESEARCH, 2022, 10 (12)
  • [6] RUNX2, the Master Regulator of Bone Metastasis?
    McCabe, F. J.
    Courtney, D.
    Jadaan, M.
    McCabe, J. P.
    Kerin, M. J.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2018, 187 : 322 - 322
  • [7] RUNX2, the master regulator of bone metastasis?
    McCabe, F. J.
    Courtney, D.
    Jadaan, M. M.
    McCabe, J. P.
    Kerin, M. J.
    BRITISH JOURNAL OF SURGERY, 2017, 104 : 36 - 36
  • [8] Runx2 Deficiency in Osteoblasts Promotes Myeloma Resistance to Bortezomib By Increasing TSP-1-Dependent TGF-β1 Activation in Bone Marrow
    Zhang, Chao
    Xu, Xiaoxuan
    Trotter, Timothy
    Javed, Amjad
    Murphy-Ullrich, Joanne E.
    Li, Juan
    Yang, Yang
    BLOOD, 2021, 138
  • [9] Myeloma Cell-Derived Runx2 Promotes Myeloma Progression and Bone-Homing
    Li, Mei
    Trotter, Timothy N.
    Peker, Deniz
    Rowan, Patrick D.
    Pan Qianying
    Larry, Suva J.
    Javed, Amjad
    Yang, Yang
    BLOOD, 2014, 124 (21)
  • [10] Runx2 Deficiency in Osteoblasts Promotes Myeloma Resistance to Bortezomib by Increasing TSP-1-Dependent TGFβ1 Activation and Suppressing Immunity in Bone Marrow
    Zhang, Chao
    Xu, Xiaoxuan
    Trotter, Timothy N.
    Gowda, Pramod S.
    Lu, Yun
    Suto, Mark J.
    Javed, Amjad
    Murphy-Ullrich, Joanne E.
    Li, Juan
    Yang, Yang
    MOLECULAR CANCER THERAPEUTICS, 2022, 21 (02) : 347 - 358