A convenient synthesis of 3-cyano-4-imino-2-methylthio-4H-pyrimido [2,1-b] [1,3] benzothiazole and its reactions with selected nucleophiles

被引：26
|
作者：
Pingle, Mayura S.
Vartale, Sambhaji P.
Bhosale, Vijay N.
Kuberkar, Sharad V. [1 ]
机构：
[1] Post Grad Res Ctr, Dept Chem, Nanded 431602, India
[2] Govt Coll Pharm, Dept Pharmaceut Chem, Aurangabad 431005, Maharashtra, India
来源：
ARKIVOC | 2006年
关键词：
2-amino-6H-methylbenzothiazole; bis(methylthio)methylenemalononitrile; 3-cyano-4-imino-2-methylthio-4H-pyrimido [2,1b] [1,3] benzothiazole;
D O I：
10.3998/ark.5550190.0007.a22
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-Amino benzothiazole (1) and 2-amino-6-methyl benzothiazole (4) in N, N'-dimethyl formamide (DMF) and anhydrous potassium carbonate reacted with bis(methylthio) methylene malononitrile (2) to afford 3-cyano-4-imino-2-methylthio-4H-pyrimido [2,1-b] [1,3] benzothiazole (3) and 3-cyano-4-imino-2-methylthio-8-methyl-4H-pyrimido [2,1-b] [1,3] benzothiazole (5), respectively. The latter were further reacted with selected N-, O- and C- nucleophiles such as aryl and hetaryl amines, substituted phenols and compounds with an active methylene group.
引用
收藏
页码：190 / 198
页数：9
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