SCORE POSSIBLE RELATIONSHIP OF METABOLIC PHENOTYPE IN OBESITY AND PERIODONTAL TISSUE CONDITION INDICATORS

Goal of research: Studying of features of clinical, laboratory and functional indicators of periodontal tissues, their relationship with serum leptin level in patients with different phenotypes of obesity. Material and methods: we Examined 90 patients aged 40-60 years (mean age 52,3 years), out of whomwere 52 men and 38 women with body mass index (BMI) = 30 kg/m2. The patients were divided into two groups of comparable by age and sex, depending on clinical and laboratory criteria of various metabolic phenotypes of obesity. Results: All 49 (100%) patients with signs of metabolic phenotype of unhealthy obesity identified clinical signs of chronic generalized periodontitis currents I-II degree. In the second group of studies similar clinical signs of chronic generalized periodontitis currents I-II degree were installed at 36 (87,8%) patients. The clinical course of generalized periodontitis patients with unhealthy obesity phenotype characterized metabolically more pronounced pathological changes in the periodontal tissues of an inflammatory nature. Observed a significant increase of proinflammatory cytokines IL-6, TNF-a and IL-4 and decrease the secretory IgA in oral fluid and blood serum. State of the Microcirculatory bed of periodontal tissues was characterized by a marked increase in peripheral resistance, vasoconstriction of blood perfusion of impoverished and periodontal tissues. In patients with metabolic obesity phenotype showed an unhealthy significant increase of leptin in the blood serum. Increased leptin levels and index NOMA correlated with major clinical laboratory and functional state of periodontal tissues. Conclusions: comparative assessment of periodontal tissues in patients with different phenotypes of obesity found that metabolically unhealthy obesity phenotype associated with a higher risk of formation of generalized periodontitis chronic flow. Status of periodontal tissues in patients with insulin resistance characterized by pronounced inflammatory changes in the system of regulation of cytokine imbalance, interrelated with the changes of metabolism of adipose tissue. Changes of clinical, laboratory and functional indicators of periodontal tissues in the formation of generalized periodontitis in patients with metabolic phenotype unhealthy obesity correlates with an increase in leptin levels and index of NOMA.