A case of atopic dermatitis-associated lichen amyloidosis successfully treated with oral cyclosporine and narrow band UVB therapy in succession

Lichen amyloidosis (LA) is a chronic, severely pruritic skin disease characterized by deposition of amyloid in the skin with no visceral involvement. Current treatments of LA are unsatisfactory, with high relapse rates, complications, and treatment failures. A 31-year-old woman with a history of refractory atopic dermatitis (AD) presented with pruritic, multiple, discrete papules on the extremities and back. Histopathologic examination confirmed the diagnosis of LA. A treatment regimen of oral cyclosporine and subsequent narrow band UVB (NBUVB) for a total of 8 months resulted in nearly complete regression. Although further studies are required to define the exact mechanism of action of this treatment regimen (oral cyclosporine + NBUVB), it seems to be an effective alternative in treating patients with LA and/or AD-associated LA.