Synthesis of albumin/DCP nano-composite particles

被引：3
|
作者：
Ohsawa, Hajime [1 ]
Ito, Atsuo [2 ]
Sogo, Yu [2 ]
Yamazaki, Atsushi [1 ]
Ohno, Tadao [1 ]
机构：
[1] Waseda Univ, Dept Resources & Environm Engn, Sch Sci & Technol, Shinjuku Ku, 3-4-1 Okubo, Tokyo 1698555, Japan
[2] Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Tsukuba, Ibaraki 3058566, Japan
来源：
BIOCERAMICS, VOL 19, PTS 1 AND 2 | 2007年 / 330-332卷
关键词：
dicalcium phosphate anhydrate; bovine serum albumin; coprecipitation; nano particles; drug delivery vehicle;
D O I：
10.4028/www.scientific.net/KEM.330-332.239
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Highly disgregated dicalcium phosphate anhydrate (DCP) nanoparticles 240-367 nm in diameter were synthesized by a reaction between calcium carbonate and phosphoric acid. When the DCP nanoparticles were immersed in a supersaturated calcium phosphate solution containing bovine serum albumin (BSA) and ethanol, BSA/DCP nano-composite particles were synthesized through the coprecipitation of BSA on the DCP nanoparticles. BSA was firmly immobilized on the BSA/DCP nano-composite particles. The results of this study suggest that DCP nanoparticles appear to be useful as a drug delivery vehicle.
引用
收藏
页码：239 / +
页数：2
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