1,2,3-Triazoles as leaving groups: SNAr reactions of 2,6-bistriazolylpurines with O- and C-nucleophiles

被引：6

作者：

Cirule, Dace ^{[1
]}

Novosjolova, Irina ^{[1
]}

Bizdena, Erika ^{[1
]}

Turks, Maris ^{[1
]}

机构：

[1] Riga Tech Univ, Fac Mat Sci & Appl Chem, P Valdena Str 3, LV-1048 Riga, Latvia

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 17卷

关键词：

2,6-bistriazolyl purines; nucleophilic aromatic substitution; purine nucleosides; triazoles; CROSS-COUPLING REACTIONS; ADENOSINE RECEPTOR AGONISTS; PURINE NUCLEOSIDES; CHEMICAL-SYNTHESIS; DERIVATIVES; ANALOGS; GUANINE; 6-HALOPURINES; GLYCOSYLATION; INHIBITORS;

D O I：

10.3762/bjoc.17.37

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach was designed for the synthesis of C6-substituted 2-triazolylpurine derivatives. A series of substituted products was obtained in SNAr reactions between 2,6-bistriazolylpurine derivatives and O- and C-nucleophiles under mild conditions. The products were isolated in yields up to 87%. The developed C-O and C-C bond forming reactions clearly show the ability of the 1,2,3-triazolyl ring at the C6 position of purine to act as leaving group.

引用

页码：410 / 419

页数：10

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