The terminal complement inhibitor eculizumab reduces thrombosis in patients with paroxysmal nocturnal hemoglobinuria.

被引：0
|
作者：
Hillmen, Peter
Muus, Petra
Duehrsen, Ulrich
Risitano, Antonio M.
Schubert, Joerg
Young, Neal S.
Schrezenmeier, Hubert
Szer, Jeffrey
Brodsky, Robert A.
Hill, Anita
Socie, Gerard
Rollins, Scott A.
Rother, Russell P.
Bell, Leonard
Luzzatto, Lucio
机构：
[1] Leeds Gen Infirm, Leeds, W Yorkshire, England
[2] Radboud Univ Nijmegen, Nijmegen, Netherlands
[3] Univ Hosp, Sch Med, Essen, Germany
[4] Mediche Federico Univ 2, NIH, Naples, Italy
[5] Saarland Univ, Homburg, Germany
[6] NHLBI, Bethesda, MD USA
[7] Inst Clin Transfusionmedizi & Immungenetikn, Helmholtzstr, Germany
[8] Royal Hosp, INSERM, Melbourne, Vic, Australia
[9] Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA
[10] Hop St Louis, Paris, France
[11] Alexion Pharmaceut Inc, Cheshire, CT USA
[12] Ins Toscano Tumori, Florence, Italy
来源：
BLOOD | 2006年 / 108卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
123
引用
收藏
页码：40A / 41A
页数：2
相关论文
共 50 条
  • [1] Theterminal complement inhibitor eculizumab reduces thrombosis in patients with paroxysmal nocturnal hemoglobinuria
    Hillmen, P.
    Muus, P.
    Duehrsen, U.
    Risitano, A.
    Schubert, J.
    Young, N. S.
    Schrezenmeier, H.
    Szer, J.
    Brodsky, R. A.
    Hill, A.
    Socie, G.
    Bessler, M.
    Rollins, S. A.
    Rother, R. P.
    Bell, L.
    Luzzatto, L.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 138 - 138
  • [2] The terminal complement inhibitor eculizumab reduces thrombosis in patients with paroxysmal nocturnal haemoglobinuria
    Hillmen, P.
    Hill, A.
    Muus, P.
    Duhrsen, U.
    Risitano, A. M.
    Schubert, J.
    Young, N. S.
    Schrezenmeier, H.
    Szer, J.
    Brodsky, R. A.
    Socie, G.
    Rollins, S. A.
    Rother, R. P.
    Bell, L.
    Luzzatto, L.
    BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 : 34 - 34
  • [3] The complement inhibitor eculizumab improves anemia and reduces thrombosis in paroxysmal nocturnal hemoglobinuria (PNH) patients
    Risitano, A. M.
    Hillmen, P.
    Young, N. S.
    Muus, P.
    Duehrsen, U.
    Schubert, J.
    Schrezenmeier, H.
    Szer, J.
    Brodsky, R. A.
    Hill, A.
    Socie, G.
    Maciejewski, J. P.
    Rollins, S. A.
    Rother, R. P.
    Bell, L.
    Marinelli, F.
    Antonioli, E.
    Lori, A. P.
    Rodeghiero, F.
    Zanella, A.
    Luzzatto, L.
    Rotoli, B.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 88 - 88
  • [4] The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria
    Hillmen, Peter
    Young, Neal S.
    Schubert, Joerg
    Brodsky, Robert A.
    Socie, Gerard
    Muus, Petra
    Roeth, Alexander
    Szer, Jeffrey
    Elebute, Modupe O.
    Nakamura, Ryotaro
    Browne, Paul
    Risitano, Antonio M.
    Hill, Anita
    Schrezenmeier, Hubert
    Fu, Chieh-Lin
    Maciejewski, Jaroslaw
    Rollins, Scott A.
    Mojcik, Christopher F.
    Rother, Russell P.
    Luzzatto, Lucio
    NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (12): : 1233 - 1243
  • [5] Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria
    Hillmen, Peter
    Muus, Petra
    Duhrsen, Ulrich
    Risitano, Antonio M.
    Schubert, Jorg
    Luzzatto, Lucio
    Schrezenmeier, Hubert
    Szer, Jeffrey
    Brodsky, Robert A.
    Hill, Anita
    Socie, Gerard
    Bessler, Monica
    Rollins, Scott A.
    Bell, Leonard
    Rother, Russell P.
    Young, Neal S.
    BLOOD, 2007, 110 (12) : 4123 - 4128
  • [6] Genetic predisposition to thrombosis in patients with paroxysmal nocturnal hemoglobinuria.
    Zimmerman, SA
    Heumayer, S
    Hall, SE
    Rosse, WF
    Ware, RE
    BLOOD, 1997, 90 (10) : 2721 - 2721
  • [7] EFFICACY OF THE COMPLEMENT INHIBITOR ECULIZUMAB IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PATIENTS NEVER TRANSFUSED
    Risitano, A.
    Alfinito, F.
    Seneca, E.
    Marando, L.
    Boschetti, C.
    Bonfigli, S.
    Fenu, S.
    Re, F.
    Gosetti, G.
    Khursigara, G.
    Rother, R.
    Zanella, A.
    Rotoli, B.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 237 - 237
  • [8] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial
    Yuzuru Kanakura
    Kazuma Ohyashiki
    Tsutomu Shichishima
    Shinichiro Okamoto
    Kiyoshi Ando
    Haruhiko Ninomiya
    Tatsuya Kawaguchi
    Shinji Nakao
    Hideki Nakakuma
    Jun-ichi Nishimura
    Taroh Kinoshita
    Camille L. Bedrosian
    Marye Ellen Valentine
    Gus Khursigara
    Keiya Ozawa
    Mitsuhiro Omine
    International Journal of Hematology, 2011, 93 : 36 - 46
  • [9] Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
    Rother, Russell P.
    Rollins, Scott A.
    Mojcik, Christopher F.
    Brodsky, Robert A.
    Bell, Leonard
    NATURE BIOTECHNOLOGY, 2007, 25 (11) : 1256 - 1264
  • [10] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial
    Kanakura, Yuzuru
    Ohyashiki, Kazuma
    Shichishima, Tsutomu
    Okamoto, Shinichiro
    Ando, Kiyoshi
    Ninomiya, Haruhiko
    Kawaguchi, Tatsuya
    Nakao, Shinji
    Nakakuma, Hideki
    Nishimura, Jun-ichi
    Kinoshita, Taroh
    Bedrosian, Camille L.
    Valentine, Marye Ellen
    Khursigara, Gus
    Ozawa, Keiya
    Omine, Mitsuhiro
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2011, 93 (01) : 36 - 46
12345