Zika Virus Infection and Guillain-Barre Syndrome in Three Patients from Suriname

被引：16

作者：

Langerak, Thomas ^{[1
]}

Yang, Harvey ^{[2
]}

Baptista, Mark ^{[3
]}

Doornekamp, Laura ^{[1
]}

Kerkman, Tessa ^{[1
]}

Codrington, John ^{[4
]}

Roosblad, Jimmy ^{[4
]}

Vreden, Stephen G. S. ^{[5
]}

De Bruin, Erwin ^{[1
]}

Mogling, Ramona ^{[1
]}

Jacobs, Bart C. ^{[6
,7
]}

Pas, Suzan D. ^{[1
]}

GeurtsvanKessel, Corine H. ^{[1
]}

Reusken, Chantal B. E. M. ^{[1
]}

Koopmans, Marion P. ^{[1
]}

Van Gorp, Eric C. M. ^{[1
]}

Alberga, Henk ^{[2
]}

机构：

[1] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[2] Acad Hosp Paramaribo, Dept Neurol, Paramaribo, Suriname

[3] St Vincentius Hosp, Dept Neurol, Paramaribo, Suriname

[4] Acad Hosp Paramaribo, Diagnost Lab, Paramaribo, Suriname

[5] Acad Hosp Paramaribo, Dept Internal Med, Paramaribo, Suriname

[6] Erasmus MC, Dept Neurol, Rotterdam, Netherlands

[7] Erasmus MC, Dept Immunol, Rotterdam, Netherlands

来源：

FRONTIERS IN NEUROLOGY | 2016年 / 7卷

关键词：

Zika virus; Guillain-Barre syndrome; Flavivirus infections; acute flaccid paralysis; emerging infectious disease; VALIDATION;

D O I：

10.3389/fneur.2016.00233

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present three patients from Suriname who were diagnosed with Guillain-Barre syndrome (GBS) during the Zika virus (ZIKV) outbreak in this country. One patient had a positive ZIKV urine real-time RT-PCR (qRT-PCR) result. The other two patients had a negative ZIKV urine qRT-PCR but a positive virus neutralization test and presence of IgG antibodies against ZIKV in the serum. Considering the evidence of a past ZIKV infection and absence of evidence for recent infections with the most common preceding infections of GBS, it is very likely that these GBS cases were triggered by ZIKV.

引用

页数：5

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