Histone methylation in transcriptional control

被引：724
|
作者：
Kouzarides, T
机构：
[1] Univ Cambridge, Wellcome CRC Inst, Cambridge CB2 1QR, England
[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1QR, England
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(02)00287-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Over the past year or so, methylation of histories has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyllysine 'mark' on histories. Methylated histories have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation.
引用
收藏
页码：198 / 209
页数：12
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