Evaluation of Drug Release Kinetics of Temozolomide Loaded Plga Nanoparticles in Pluronic? F-127 Hydrogel

Objective: Controlled local release of temozolomide (TMZ) at the tumor site is a new strategy in the treatment of glioblastoma. Localized delivery systems, based on biodegradable polymers, are capable of slowing and controlling the drug release for a certain period of time. Therefore, the main objective of the study was to investigate a new approach for encapsulating TMZ in a poly(lactic-co-glycolic acid) nanoparticle (NP) system which was then formulated in 18% Pluronic (R) hydrogel matrix which would provide a sustained and local delivery of TMZ.Methods: Hydrogels are investigated as local drug delivery methods due to their tunable characteristics and capacity to retain labile pharmaceuticals. The lack of established procedures for describing and evaluating drug release, on the other hand, offers considerable problems, impeding reliable evaluation of systems for defining drug release characteristics.Results: In this part our study, we aimed to research drug release kinetics of TMZ NPs which had an encapsulation efficiency and particle size ranging between 52-69.67% and 164.4-235.5 nm from a novel hydrogel drug delivery system.Conclusion: The application of mathematical modeling proves to be extremely beneficial for estimating the release kinetics before the release systems are implemented. The release mechanism was found to be diffusion controlled and not accompanied by dissolution of matrix.