Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia

被引：41

作者：

Hraiech, Sami ^{[1
,2
]}

Roch, Antoine ^{[1
,2
]}

Lepidi, Hubert ^{[1
,3
]}

Atieh, Therese ^{[1
]}

Audoly, Gilles ^{[1
]}

Rolain, Jean-Marc ^{[1
,4
,6
]}

Raoult, Didier ^{[1
,4
]}

Brunel, Jean-Michel

Papazian, Laurent ^{[1
,2
]}

Bregeon, Fabienne ^{[1
,5
]}

机构：

[1] Aix Marseille Univ, URMITE, CNRS 7278, IRD 198,UM63,INSERM 1095, Marseille, France

[2] Reanimat, CHU Nord, APHM, Marseille, France

[3] Serv Anat Pathol, CHU Timone, APHM, Marseille, France

[4] Pole Infectieux, CHU Timone, APHM, Marseille, France

[5] Serv Explorat Fonct Respiratoires, CHU Nord, APHM, Marseille, France

[6] Aix Marseille Univ, Fac Pharm, INSERM, CRCM,CNRS,UMR 7258,U 1068, Marseille, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 10期

关键词：

FRANCE; MARSEILLES;

D O I：

10.1128/AAC.00700-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronounced signs of infection (lung bacterial count, systemic dissemination, and lung damage) and a better outcome (ABCR and ABCS mortality rates, 20 and 50%, respectively [P = 0.03]).

引用

页码：5120 / 5121

页数：2

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