Reduced Graphene Oxide Functionalized with a Luminescent Rare-Earth Complex for the Tracking and Photothermal Killing of Drug-Resistant Bacteria

被引:69
|
作者
Yang, Xinjian [1 ,2 ,3 ]
Li, Zhenhua [1 ,2 ,3 ]
Ju, Enguo [1 ,2 ,3 ]
Ren, Jinsong [1 ,2 ]
Qu, Xiaogang [1 ,2 ]
机构
[1] Acad Sinica, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Peoples R China
[2] Acad Sinica, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
基金
中国国家自然科学基金;
关键词
imaging; luminescent complexes; rare-earth complexes; photothermal killing; reduced graphene oxide; BIOFUNCTIONAL MAGNETIC NANOPARTICLES; NEAR-INFRARED ABSORBENCY; GRAM-NEGATIVE BACTERIA; CANCER-THERAPY; CARBON NANOTUBES; AGENTS; RELEASE; LIGHT; HYPERTHERMIA; PROBES;
D O I
10.1002/chem.201303964
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An antibacterial platform based on multifunctional reduced graphene oxide (rGO) that is responsive to near-infrared (NIR) light has been constructed. By introducing a luminescent Eu3+ complex and vancomycin for bacteria tracking into one system, this platform could specifically recognize and light up bacteria. Antibacterial activity of this nanoscale construction under NIR illumination was investigated. Upon illumination with NIR light, this nanoscale architecture generates great heat locally, resulting in the death of drug-resistant bacteria. These results indicate that the ability of this nanoscale platform to kill drug-resistant bacteria has great potential for clinical pathogenic bacteria diagnosis and treatment.
引用
收藏
页码:394 / 398
页数:5
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