Phospholipase Cγ Signaling in Bone Marrow Stem Cell and Relevant Natural Compounds Therapy

被引：2
|
作者：
Liu, Chang [1 ,2 ]
He, Yuan [3 ]
Xu, Xiaobing [4 ]
He, Baorong [1 ]
机构：
[1] Xi An Jiao Tong Univ, Dept Spine Surg, Honghui Hosp, Xian, Peoples R China
[2] Shaanxi Univ Chinese Med, Xian Yang, Peoples R China
[3] Fifth Hosp Xian, Dept Orthoped, Xian, Peoples R China
[4] Southern Med Univ, Dept Neurosurg, Shunde Hosp, Fo Shan, Peoples R China
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2020年 / 15卷 / 07期
关键词：
Phospholipase C gamma signaling; calcium signaling; osteoclast; natural occurring compounds; bone marrow stem cell; osteoporosis; INHIBITS OSTEOCLAST DIFFERENTIATION; NF-KAPPA-B; RANKL-INDUCED OSTEOCLASTOGENESIS; OLEANOLIC ACID; SUPPRESSES OSTEOCLASTOGENESIS; AIRWAY INFLAMMATION; BIOLOGICAL-ACTIVITY; METHYL GALLATE; IN-VITRO; EXTRACT;
D O I：
10.2174/1574888X14666191107103755
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Excessive bone resorption has been recognized play a major role in the development of bone-related diseases such as osteoporosis, rheumatoid arthritis, Paget's disease of bone, and cancer. Phospholipase C gamma (PLC gamma) family members PLC gamma 1 and PLC gamma 2 are critical regulators of signaling pathways downstream of growth factor receptors, integrins, and immune complexes and play a crucial role in osteoclast. Ca2+ signaling has been recognized as an essential pathway to the differentiation of osteoclasts. With growing attention and research about natural occurring compounds, the therapeutic use of natural active plant-derived products has been widely recognized in recent years. In this review, we summarized the recent research on PLC gamma signaling in bone marrow stem cells and the use of several natural compounds that were proven to inhibit RANKL-mediated osteoclastogenesis via modulating PLC gamma signaling pathways.
引用
收藏
页码：579 / 587
页数：9
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