MYH9 is associated with nondiabetic end-stage renal disease in African Americans

被引：508

作者：

Kao, W. H. Linda ^{[1
,2
,3
]}

Klag, Michael J. ^{[1
,2
,3
]}

Meoni, Lucy A. ^{[2
,3
,4
,5
]}

Reich, David ^{[6
,7
,8
]}

Berthier-Schaad, Yvette ^{[1
]}

Li, Man ^{[1
]}

Coresh, Josef ^{[1
,3
,4
,5
]}

Patterson, Nick ^{[7
,8
]}

Tandon, Arti ^{[6
,7
,8
]}

Powe, Neil R. ^{[1
,2
,3
]}

Fink, Nancy E. ^{[1
,2
,3
]}

Sadler, John H. ^{[9
]}

Weir, Matthew R. ^{[9
]}

Abboud, Hanna E. ^{[10
]}

Adler, Sharon G. ^{[11
]}

Divers, Jasmin ^{[12
]}

Iyengar, Sudha K. ^{[13
]}

Freedman, Barry I. ^{[12
]}

Kimmel, Paul L. ^{[14
]}

Knowler, William C. ^{[15
]}

Kohn, Orly F. ^{[16
]}

Kramp, Kristopher ^{[13
]}

Leehey, David J. ^{[17
]}

Nicholas, Susanne B. ^{[18
]}

Pahl, Madeleine V. ^{[19
]}

Schelling, Jeffrey R. ^{[20
]}

Sedor, John R. ^{[20
,21
]}

Thornley-Brown, Denyse ^{[22
]}

Winkler, Cheryl A. ^{[23
]}

Smith, Michael W. ^{[23
]}

Parekh, Rulan S. ^{[1
,2
,3
,24
]}

机构：

[1] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Dept Med, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Dept Biostat, Sch Med, Baltimore, MD 21287 USA

[5] Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21287 USA

[6] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[7] Harvard Univ, Broad Inst, Cambridge, MA 02142 USA

[8] MIT, Cambridge, MA 02142 USA

[9] Univ Maryland, Dept Med, Baltimore, MD 21201 USA

[10] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA

[11] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Med, Los Angeles, CA 90502 USA

[12] Wake Forest Univ, Bowman Gray Sch Med, Dept Med, Winston Salem, NC 27157 USA

[13] Case Western Reserve Univ, Sch Med, Dept Epidemiol & Biostat, Cleveland, OH 44109 USA

[14] NIDDK, NIH, Bethesda, MD 20892 USA

[15] NIDDK, Diabet Epidemiol & Clin Res Sect, NIH, Phoenix, AZ 85014 USA

[16] Loyola Univ, Dept Med, Chicago, IL 60153 USA

[17] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[18] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90024 USA

[19] Univ Calif Irvine, Dept Med, Irvine, CA 92868 USA

[20] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44109 USA

[21] Case Western Reserve Univ, Sch Med, Dept Biophysiol & Biophys, Cleveland, OH 44109 USA

[22] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[23] NCI, Lab Genom Divers, SAIC Frederick Inc, Frederick, MD 21702 USA

[24] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 10期

基金：

美国国家卫生研究院; 美国医疗保健研究与质量局;

关键词：

D O I：

10.1038/ng.232

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.

引用

下载

页码：1185 / 1192

页数：8

共 50 条

[1] MYH9 is associated with nondiabetic end-stage renal disease in African Americans
W H Linda Kao
Michael J Klag
Lucy A Meoni
David Reich
Yvette Berthier-Schaad
Man Li
Josef Coresh
Nick Patterson
Arti Tandon
Neil R Powe
Nancy E Fink
John H Sadler
Matthew R Weir
Hanna E Abboud
Sharon G Adler
Jasmin Divers
Sudha K Iyengar
Barry I Freedman
Paul L Kimmel
William C Knowler
Orly F Kohn
Kristopher Kramp
David J Leehey
Susanne B Nicholas
Madeleine V Pahl
Jeffrey R Schelling
John R Sedor
Denyse Thornley-Brown
Cheryl A Winkler
Michael W Smith
Rulan S Parekh
Nature Genetics, 2008, 40 : 1185 - 1192
[2] MYH9 is associated with kidney disease in African Americans
不详
Nature Clinical Practice Nephrology, 2009, 5 (1): : 2 - 3
[3] Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans
Freedman, Barry I.
Hicks, Pamela J.
Bostrom, Meredith A.
Cunningham, Mary E.
Liu, Yongmei
Divers, Jasmin
Kopp, Jeffrey B.
Winkler, Cheryl A.
Nelson, George W.
Langefeld, Carl D.
Bowden, Donald W.
KIDNEY INTERNATIONAL, 2009, 75 (07) : 736 - 745
[4] Double nucleotidic mutation of the MYH9 gene in a young patient with end-stage renal disease
Capria, M
Andreucci, M
Fuiano, L
Mancuso, D
Cianfrone, P
Comi, N
Mazza, G
Caglioti, A
Fuiano, G
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2004, 19 (01) : 249 - 251
[5] Non-diabetic end-stage renal disease in Saudis associated with polymorphism of MYH9 gene but not UMOD gene
Adam, Khalid Mohamed
Mohammed, Ali Mahmoud
Elamin, Abubakr Ali
MEDICINE, 2020, 99 (03)
[6] African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans
Behar, Doron M.
Rosset, Saharon
Tzur, Shay
Selig, Sara
Yudkovsky, Guennady
Bercovici, Sivan
Kopp, Jeffrey B.
Winkler, Cheryl A.
Nelson, George W.
Wasser, Walter G.
Skorecki, Karl
HUMAN MOLECULAR GENETICS, 2010, 19 (09) : 1816 - 1827
[7] The epidemiology of end-stage renal disease among African Americans
Martins, D
Tareen, N
Norris, KC
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2002, 323 (02): : 65 - 71
[8] Marriage and End-Stage Renal Disease: Implications for African Americans
Shortridge, Emily F.
James, Cara V.
JOURNAL OF FAMILY ISSUES, 2010, 31 (09) : 1230 - 1249
[9] Identification of podocin (NPHS2) gene mutations in African Americans with nondiabetic end-stage renal disease
Dusel, JAE
Burdon, KP
Hicks, PJ
Hawkins, GA
Bowden, DW
Freedman, BI
KIDNEY INTERNATIONAL, 2005, 68 (01) : 256 - 262
[10] Patterns of end-stage renal disease in US African-Americans
Agodoa, L
NEPHROLOGY, 1998, 4 : S12 - S16

← 1 2 3 4 5 →