Association Between Interictal High-Frequency Oscillations and Slow Wave in Refractory Focal Epilepsy With Good Surgical Outcome

被引:7
|
作者
Ren, Guoping [1 ,2 ]
Yan, Jiaqing [3 ]
Sun, Yueqian [1 ,2 ,4 ]
Ren, Jiechuan [1 ,2 ]
Dai, Jindong [5 ]
Mei, Shanshan [5 ]
Li, Yunlin [5 ]
Wang, Xiaofei [5 ]
Yang, Xiaofeng [4 ,6 ,7 ]
Wang, Qun [1 ,2 ,4 ]
机构
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China
[2] China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
[3] North China Univ Technol, Coll Elect & Control Engn, Beijing, Peoples R China
[4] Capital Med Univ, Beijing Inst Brain Disorders, Collaborat Innovat Ctr Brain Disorders, Lab Brain Disorders, Beijing, Peoples R China
[5] Beijing Haidian Hosp, Dept Funct Neurosurg, Beijing, Peoples R China
[6] Capital Med Univ, Xuanwu Hosp, Neuroelectrophysiol Lab, Beijing, Peoples R China
[7] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou, Peoples R China
来源
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
high-frequency oscillations; slow wave; refractory focal epilepsy; good surgical outcome; epileptogenic zone; CORTICAL SYNCHRONIZATION; SLEEP HOMEOSTASIS; RIPPLES; STATE;
D O I
10.3389/fnhum.2020.00335
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
High-frequency oscillations (HFOs) have been proposed as a promising biomarker of the epileptogenic zone (EZ). But accurate delineation of EZ based on HFOs is still challenging. Our study compared HFOs from EZ and non-EZ on the basis of their associations with interictal slow waves, aiming at exploring a new way to localize EZ. Nineteen medically intractable epilepsy patients with good surgical outcome were included. Five minute interictal intracranial electroencephalography (EEG) epochs of slow-wave sleep were randomly selected; then ripples (80-200 Hz), fast ripples (FRs; 200-500 Hz), and slow waves (0.1-4 Hz) were automatically analyzed. The EZ and non-EZ were identified by resection range during the surgeries. We found that both ripples and FRs superimposed more frequently on slow waves in EZ than in non-EZ (P< 0.01). Although ripples preferred to occur on the down state of slow waves in both two groups, ripples in EZ tended to be closer to the down-state peak of slow wave than in non-EZ (-174 vs. -231 ms,P= 0.008). As for FR, no statistical difference was found between the two groups (P= 0.430). Additionally, slow wave-containing ripples in EZ had a steeper slope (1.7 vs. 1.5 mu V/ms,P< 0.001) and wider distribution ratio (32.3 vs. 30.1%,P< 0.001) than those in the non-EZ. But for slow wave-containing FR, only a steeper slope (1.7 vs. 1.4 mu V/ms,P< 0.001) was observed. Our study innovatively compared the different features of association between HFOs and slow wave in EZ and non-EZ from refractory focal epilepsy with good surgical outcome, proposing a new method to localize EZ and facilitating the surgical plan.
引用
收藏
页数:10
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