Activity-dependent regulation of excitability in rat visual cortical neurons

被引：10
|
作者：
Desai, NS
Nelson, SB
Turrigiano, GG
机构：
[1] Brandeis Univ, Dept Biol, Waltham, MA 02454 USA
[2] Brandeis Univ, Ctr Complex Syst, Waltham, MA 02454 USA
来源：
NEUROCOMPUTING | 1999年 / 26-7卷
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
development; excitable membranes; learning and memory;
D O I：
10.1016/S0925-2312(99)00004-1
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
A neuron's electrical properties are produced by a variety of voltage- and time-dependent ionic conductances. Here we examine how activity deprivation affects the excitability and ionic currents of cultured cortical pyramidal neurons. Blocking activity for 48 h results in a marked increase in excitability, mediated by changes in sodium and persistent potassium currents. This finding suggests that neurons can control their firing rates by tuning their distribution of ionic conductances in response to changes in activity. (C) 1999 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：101 / 106
页数：6
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