Novel possibilities of antithrombotic therapy in patients with chronic heart failure

被引：0
|
作者：
Olbinskaya, LI [1 ]
Kolosova, K [1 ]
Nesterova, SG [1 ]
Egorova, TD [1 ]
Fedorova, AY [1 ]
机构：
[1] IM Sechenov Med Acad, Moscow 119881, Russia
来源：
KARDIOLOGIYA | 2005年 / 45卷 / 12期
关键词：
thrombosis; thromboembolism; venous; heart failure; chronic; enoxaparin;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Modern approaches to prevention of venous thromboembolic complications in patients with chronic heart failure are analyzed in this review which contains results of large studies of low molecular weight heparins. In MEDENOX trial the use of enoxaparin in medical patients was associated with 63% reduction of risk of thrombosis. The authors own experience showed that 2 weeks of therapy with enoxaparin in patients with chronic stage IIB-III heart failure caused significant lowering of soluble fibrin-monomer complexes, fibrinogen, and index of turbodynamic potential. These changes evidenced for decreased intravascular blood coagulation. Thus enoxaparin can be effectively used for prevention of thrombosis and thromboembolism in patients with chronic heart failure. Novel antithrombotic agents fondaparinux, idraparinux, ximelagatran, recombinant thrombomodulin are perspective medications for prevention of venous thromboses and embolism in medical patients.
引用
收藏
页码：93 / 98
页数：6
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