Transcriptomics and quantitative proteomics in virology

Viral proteins and their roles in virus replication are typically well understood. However, their interactions with host proteins are currently not as well defined, and a better understanding may lead to novel findings involving virus replication, pathogenicity, host immune responses and antiviral therapies. With recent advances in 'omic' technologies, it is now possible to simultaneously monitor thousands of host gene and protein modification levels in response to viral infections, both in vitro and in vivo. This article aims to discuss the most common techniques used for studying virus-induced host changes, as well as useful software tools for subsequent data analysis and the impact these studies have had on the field of virology.