Effects of Diet on Telomere Length: Systematic Review and Meta-Analysis

被引:32
|
作者
Perez, Lisiane Marcal [1 ]
Amaral, Marina Azambuja [1 ]
Mundstock, Eduardo [1 ]
Barbe-Tuana, Florencia M. [2 ]
Costa Rodrigues Guma, Fatima Teresinha [2 ]
Jones, Marcus H. [1 ]
Machado, Denise Cantarelli [1 ]
Sarria, Edgar E. [3 ]
Marques e Marques, Maximiniano [1 ]
Preto, Luiza Tweedie [1 ]
Epifanio, Matias [1 ]
Meinem Garbin, Joao Guilherme [1 ]
Mattiello, Rita [1 ,2 ]
机构
[1] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil
[3] Univ Santa Cruz do Sul, Santa Cruz, Brazil
关键词
Age; Diet; Telomere; HALLMARKS; OBESITY; TRIAL; CELLS;
D O I
10.1159/000486586
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: The goal of this systematic review and meta-analysis is to determine the effect of diet on telomere length. Methods: We searched the following databases: MEDLINE, Embase, LILACS, CINAHL, ISI Web of Science, and Scopus, as well as the Cochrane Central Register of Controlled Trials and the National Institutes of Health, from inception to December 2016. Articles that assessed effects of diet on telomere length were included. Results: A total of 2,128 studies were identified, 30 were read in full, and 7 were systematically reviewed. Five RCTs were included in the meta-analysis, covering 9 diets; a total of 533 participants were included. Study heterogeneity (I-2) was 89%, and differences were not identified regarding average telomere lengths (mean difference 1.06; 95% CI - 1.53 to 3.65). Conclusion: The available evidence suggests that there is no effect of diet on telomere length, but the strong heterogeneity in the type and duration of dietary interventions does not allow any final statement on the absence of an effect of diet on telomere length. (c) 2018 S.Karger AG, Basel
引用
收藏
页码:286 / 292
页数:7
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