Development of Chitosan/Poly(Vinyl Alcohol) Electrospun Nanofibers for Infection Related Wound Healing

被引：35
|
作者：
Wang, Mian [1 ]
Roy, Amit K. [1 ]
Webster, Thomas J. [1 ,2 ,3 ]
机构：
[1] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA
[2] Wenzhou Med Univ, Wenzhou Inst Biomat & Engn, Wenzhou, Peoples R China
[3] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah, Saudi Arabia
来源：
FRONTIERS IN PHYSIOLOGY | 2017年 / 7卷
关键词：
nanostructures; wound healing; chitosan; fibers; polyvivl alcohol;
D O I：
10.3389/fphys.2016.00683
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Chitosan is a cheap resource, which is widely used in biomedical applications due to its biocompatible and antibacterial properties. In this study, composite nanofibrous membranes of chitosan (CS) and poly(vinyl alcohol) (PVA) loaded with antibiotics at different ratios were successfully fabricated by electrospinning. The composite nanofibers were subjected to further analysis by scanning electron microscopy (SEM). SEM images revealed that the volumetric ratio of CS/PVA at 50/50 achieved an optimal nanofibrous structure (i.e., that most similar to natural tissues) compared with other volumetric ratios, which indicated that this CS/PVA electrospun scaffold has great potential to be used for infection related wound dressing for skin tissue regeneration.
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页数：3
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