The good, the bad and the ugly A neuropilin-2 story from normal to tumor-associated lymphangiogenesis

被引：5
|
作者：
Roth, Lise [1 ]
机构：
[1] INSERM, U575, Ctr Neurochim, F-67084 Strasbourg, France
来源：
CELL ADHESION & MIGRATION | 2008年 / 2卷 / 04期
关键词：
VEGF-C; NRP2; VEGFR-3; tumoral lymphangiogenesis; metastasis;
D O I：
10.4161/cam.2.4.6960
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
VEGF-C is a crucial player in lymphangiogenesis. Besides VEGFR-2 and VEGFR-3, it also binds NRP2. NRP2 enhances VEGF-C/VEGFR-3 effects in developmental lymphangiogenesis, but its role in adult and tumoral lymphangiogenesis is not known. In their study, Bagri and colleagues demonstrate that blocking NRP2 results in a decrease of metastasis formation, a phenomenon relying on tumoral lymphangiogenesis. Thus, they identified NRP2 as an attractive new target for modulating metastasis.
引用
收藏
页码：217 / 219
页数：3
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