New insights into the metal-induced oxidative degradation pathways of transthyretin

被引：19
|
作者：
Poltash, Michael L. [1 ]
Shirzadeh, Mehdi [1 ]
McCabe, Jacob W. [1 ]
Moghadamchargari, Zahra [1 ]
Laganowsky, Arthur [1 ]
Russell, David H. [1 ]
机构：
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 28期
基金：
美国国家卫生研究院;
关键词：
MASS-SPECTROMETRY; REVEALS; FIBRIL;
D O I：
10.1039/c9cc00682f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation.
引用
收藏
页码：4091 / 4094
页数：4
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