Role of Astrocytes in glutamate homeostasis: Implications for excitotoxicity

被引：137
|
作者：
Schousboe, A [1 ]
Waagepetersen, HS [1 ]
机构：
[1] Danish Univ Pharmaceut Sci, Dept Pharmacol, DK-2100 Copenhagen, Denmark
来源：
NEUROTOXICITY RESEARCH | 2005年 / 8卷 / 3-4期
关键词：
astrocytes; glutamate; excitotoxicity; neurotoxicity;
D O I：
10.1007/BF03033975
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glutamate homeostasis in the brain is maintained by its well balanced release, uptake and metabolism. It appears that astrocytes play a prominent role in this context since they possess a very powerful battery of glutamate transporters. Thus, malfunction of astrocytic glutamate transporters will lead to an excessively high extracellular glutamate concentration which may result in neurodegeneration caused by the excitotoxic action of glutamate.
引用
收藏
页码：221 / 225
页数：5
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