Two New Adjacent Bis-Tetrahydrofuran Annonaceous Acetogenins from Seeds of Annona cornifolia

被引：13
|
作者：
Rodrigues dos Santos Lima, Luciana Alves [1 ]
Santos Pimenta, Lucia Pinheiro [1 ]
Diamantino Boaventura, Maria Amelia [1 ]
机构：
[1] Univ Fed Minas Gerais, Dept Quim, Inst Ciencias Exatas, BR-31270901 Belo Horizonte, MG, Brazil
来源：
PLANTA MEDICA | 2009年 / 75卷 / 01期
关键词：
Annona cornifolia A. St. Hil; Annonaceae; acetogenins; Cotton effect; Mosher ester derivatives; ABSOLUTE-CONFIGURATION; ASIMINA-TRILOBA; RECENT PROGRESS;
D O I：
10.1055/s-0028-1088359
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new adjacent bis-THF annonaceous acetogenins, 9-hydroxyfolianin (1) and folianin B (2), together with two known acetogenins, asimicin (3) and bullatacin (4), significantly bioactives in brine shrimp lethality test, were isolated from seeds of Annona cornifolia A. St. Hil (Annonaceae). Their structures were elucidated by NMR and ESI-MS analysis, and relative configurations were established. The absolute configuration around the THF rings of 1 was defined by Mosher esters methodology and circular dichroism.
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页码：80 / 83
页数：4
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