Synthesis of pyrrolobenzoxazepinones by CuI/L-proline-catalyzed intramolecular coupling reactions

被引：6

作者：

Huang, Aiping ^{[1
]}

Feng, Lei ^{[1
]}

Qiao, Zhi ^{[1
]}

Yu, Wei ^{[1
]}

Zheng, Qingqing ^{[1
]}

Ma, Chen ^{[1
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

来源：

TETRAHEDRON | 2013年 / 69卷 / 02期

基金：

美国国家科学基金会;

关键词：

Copper-catalyzed process; Pyrrolobenzoxazepinones; Bioactive compounds; Synthesis; N-ARYLATION; TANDEM CYCLIZATION; ARYL; SELECTIVITIES; INHIBITORS; AMINATION; EFFICIENT; HALIDES; POTENT;

D O I：

10.1016/j.tet.2012.11.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed process for the construction of pyrrolobenzoxazepinones from 2-(2-iodophenoxy)-1-(1H-pyrrol-2-yl)ethanones is described. The reaction afforded a variety of products in good to excellent yields. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：642 / 646

页数：5

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