Biological and Rheological Properties of Collagen Cross-Linked with Glutaraldehyde

被引：7
|
作者：
Nashchekina, Yu. A. [1 ,2 ]
Lukonina, O. A. [1 ]
Darvish, D. M. [1 ]
Nashchekin, A. V. [2 ]
Elokhovskii, V. Yu. [3 ]
Yudin, V. E. [3 ]
Mikhailova, N. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia
[2] Ioffe Inst, St Petersburg 194021, Russia
[3] Peter Great St Petersburg Polytech Univ, St Petersburg 195251, Russia
来源：
TECHNICAL PHYSICS | 2020年 / 65卷 / 09期
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
GEL; CYTOTOXICITY; MECHANISM; LINKING;
D O I：
10.1134/S1063784220090224
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
We study the effect of the concentration of glutaraldehyde that can cross-link type I collagen molecules on the collagen stability, mechanical strength, and cytotoxicity. It is shown that collagen containing 10 and 18% of glutaraldehyde exhibits the highest stability in physiological conditions. The results of rheological analysis demonstrate that, for the minimal concentration of glutaraldehyde (1%), mechanical characteristics of collagen hydrogels are improved significantly. However, the glutaraldehyde concentration higher than 10% reduces the vitality of cells by 50%.
引用
收藏
页码：1535 / 1540
页数：6
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