Developmental Brain Protein Level Changes in the C57BL/6J Mouse

被引：5
|
作者：
Myung, Jae-Kyung [1 ]
Shim, Ki Shuk [1 ]
Li, Lin [1 ]
Hoeger, Harald [2 ]
Lubec, Gert [1 ]
机构：
[1] Med Univ Vienna, Dept Pediat, A-1090 Vienna, Austria
[2] Med Univ Vienna, Inst Anim Genet, Himberg, Austria
来源：
JOURNAL OF PROTEOME RESEARCH | 2009年 / 8卷 / 03期
关键词：
CL57BL/6J; mouse; brain; gel-based proteomic method; two independent mass spectrometrical methods; UBIQUITIN-PROTEASOME SYSTEM; OLIGODENDROGLIAL CELL-LINES; GLUTATHIONE-S-TRANSFERASE; MOESIN ERM PROTEINS; GEL-ELECTROPHORESIS; HIPPOCAMPAL LEVELS; IN-VITRO; EXPRESSION; RAT; MICE;
D O I：
10.1021/pr800990x
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
As work on systematic searches for developmentally-regulated proteins is limited, whole brains of CL57B/6J mice were taken from day 16 of gestation, at postnatal days 7 and 54-58. Proteins were extracted, and analyzed by a gel-based proteomic method (ion trap HCT). Antioxidant, cytoskeleton, chaperone, several metabolic proteins from different pathways, proteins from the protein synthetic and degradation machinery, sirtuin and a mitochondrial inner membrane protein were developmentally regulated.
引用
收藏
页码：1207 / 1219
页数：13
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