Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain

被引：16
|
作者：
Yoshikawa, M
Andoh, H
Ito, K
Suzuki, T
Kawaguchi, M
Kobayashi, H
Oka, T
Hashimoto, A [1 ]
机构：
[1] Tokai Univ, Sch Med, Dept Pharmacol, Isehara, Kanagawa 2591143, Japan
[2] Tokai Univ, Sch Med, Dept Psychiat & Behav Sci, Isehara, Kanagawa 2591143, Japan
[3] Tokai Univ, Sch Med, Dept Anesthesiol, Isehara, Kanagawa 2591143, Japan
[4] Tokyo Dent Coll, Dept Pharmacol, Mihama Ku, Chiba 2618502, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 525卷 / 1-3期
关键词：
D-amino acid oxidase; morphine; NMDA ( N-methyl-D-aspartate) receptor; D-serine; serine racemase;
D O I：
10.1016/j.ejphar.2005.09.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To obtain further insight into the interactions between the N-methyl-D-aspartate receptor and opioid receptor systems, we have investigated the effects of the acute treatment of morphine on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The morphine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. The present results are the first to suggest an interaction between the expression of the mRNAs for the D-serine-related enzymes and the opioid receptor activation. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：94 / 97
页数：4
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