Arming oncolytic adenovirus with FAP-targeting bispecific T-cell engager to improve antitumor efficacy

被引：0
|
作者：
de Sostoa Pomes, J. [1 ]
Fajardo, C. A. [1 ]
Farrera Sal, M. [1 ]
Moreno, R. [1 ]
Arias-Badia, M. [1 ]
Rojas, L. A. [1 ]
Alemany, R. [1 ]
机构：
[1] Hosp Duran & Reynals, Bellvitge Biomed Res Inst IDIBELL, ProCURE, Lhospitalet De Llobregat, Spain
来源：
ANNALS OF ONCOLOGY | 2017年 / 28卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
61P
引用
收藏
页码：18 / 18
页数：1
相关论文
共 50 条
  • [1] Targeting the tumor stroma with a bispecific T-cell engager-armed oncolytic adenovirus
    de Sostoa Pomes, J.
    Fajardo, C. A.
    Moreno, R.
    Ramon, M. D.
    Farrera Sal, M.
    Alemany, R.
    ANNALS OF ONCOLOGY, 2018, 29 : 34 - 34
  • [2] Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy
    Alberto Fajardo, Carlos
    Guedan, Sonia
    Alfonso Rojas, Luis
    Moreno, Rafael
    Arias-Badia, Marcel
    de Sostoa, Jana
    June, Carl H.
    Alemany, Ramon
    CANCER RESEARCH, 2017, 77 (08) : 2052 - 2063
  • [3] Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager
    de Sostoa, Jana
    Alberto Fajardo, Carlos
    Moreno, Rafael
    Ramos, Maria D.
    Farrera-Sal, Marti
    Alemany, Ramon
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [4] Arming oncolytic vaccinia virus with T cell engager to improve virus therapy
    Song, Xiaotong
    Yu, Feng
    Gottschalk, Stephen
    Bartlett, David
    JOURNAL OF IMMUNOLOGY, 2013, 190
  • [5] Bi-specific T-cell engager-armed oncolytic adenoviruses as a strategy to improve antitumor efficacy
    Alberto Fajardo, Carlos
    Moreno, Rafael
    Alfonso Rojas, Luis
    Arias, Marcel
    Alemany, Ramon
    HUMAN GENE THERAPY, 2015, 26 (09) : A13 - A14
  • [6] Therapeutic bispecific T-cell engager antibody targeting the transferrin receptor
    Fu, M.
    Guo, Z.
    Tang, H.
    Zhu, H.
    Shen, G.
    Lei, P.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 1768 - 1768
  • [7] Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor
    Fu, Mingpeng
    He, Qi
    Guo, Zilong
    Zhou, Xiaoran
    Li, Heli
    Zhao, Liang
    Tang, Hongling
    Zhou, Xiaoqi
    Zhu, Huifen
    Shen, Guanxin
    He, Yong
    Lei, Ping
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [8] Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy
    You, Ran
    Artichoker, Jordan
    Ray, Arja
    Velozo, Hugo Gonzalez
    Rock, Dan A.
    Conner, Kip P.
    Krummel, Matthew F.
    CANCER IMMUNOLOGY RESEARCH, 2022, 10 (06) : 698 - 712
  • [9] Bispecific NK-cell engager targeting BCMA elicits stronger antitumor effects and produces less proinflammatory cytokines than T-cell engager
    Xiao, Xinghui
    Cheng, Ying
    Zheng, Xiaodong
    Fang, Yuhang
    Zhang, Yu
    Sun, Rui
    Tian, Zhigang
    Sun, Haoyu
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [10] Targeting T-cells to human cancer associated fibroblasts using an oncolytic virus expressing a FAP-specific T-cell engager
    Champion, Brian
    Freedman, Joshua
    Ashfield, Rebecca
    Duffy, Margaret
    Brown, Alice
    Seymour, Leonard
    Fisher, Kerry
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
12345