?Department of Electrical and Electronics Engineering Sri Shakthi Institute of Engineering and Technology Coimbatore, Tamil Nadu, India

被引:0
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作者
Jalajakumari, Suji Prasad Sudarsanan Nair [1 ]
Devaraj, Swathi [2 ]
Manivel, Thangatamilan [1 ]
Ramasamy, Sureshkumar [1 ]
机构
[1] Kongu Engn Coll, Dept Elect & Instrumentat Engn, Perundurai, Tamil Nadu, India
[2] Sri Shakthi Inst Engn & Technol, Dept Elect & Elect Engn, Coimbatore, Tamil Nadu, India
来源
关键词
apoptosis; breast cancer; cancer cell death rate; cancer cell repair rate; cell proliferation; chemotherapeutic agent; BREAST-CANCER; CHEMOTHERAPY;
D O I
10.7546/CRABS.2022.10.11
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Breast cancer is the second leading cause of cancer among women glob-ally. Several treatments are involved in breast cancer like surgery, chemother-apy, radiotherapy, and hormone therapy; chemotherapy being used most often. Multicellular systems complications can be deeply understood by analyzing and studying how cells grow, move, divide, die and interact. To examine these fac-tors, we use PhysiCell as our modelling platform. Virtual cell growth analysis is essential to view the cancer cell growth daily. PhysiCell physics-based mul-ticellular simulator is an open-source agent-based simulator used to design a virtual model to analyze the changing cell cycle progression, volume, death, motility, mechanics and processes. Analysis was made on the cancer cell death rate, cell damage rate, and cell repair rate. Data were taken for every 6 hours of simulation and the result confirms that the chemotherapeutic agent kills 45% of cancer cells.
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页码:1483 / 1490
页数:8
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