Rhodium Catalyzed Asymmetric Hydrogenation of 2-Pyridine Ketones

被引：62
|
作者：
Yang, Hailong
Huo, Ningning
Yang, Ping
Pei, Hao
Lv, Hui [1 ]
Zhang, Xumu
机构：
[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Hubei, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 17期
基金：
中国国家自然科学基金;
关键词：
HIGHLY ENANTIOSELECTIVE HYDROGENATION; IRIDIUM CATALYSTS; KINETIC RESOLUTION; PYRIDYL ALCOHOLS; CU(II)(BORABOX)-CATALYZED ACYLATION; STEREOSELECTIVE HYDROGENATION; ABSOLUTE-CONFIGURATION; HETEROAROMATIC KETONES; EFFICIENT; LIGANDS;
D O I：
10.1021/acs.orglett.5b01878
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Catalyzed by [Rh(COD)Binapine]BF4, the asymmetric hydrogenation of 2-pyridine ketones has been achieved with excellent enantioselectivities (enantiomeric excesses up to 99%) under mild conditions. This method is suitable for various kinds of 2-pyridine ketones and their derivatives. A number of enantiomerically pure chiral 2-pyridine-aryl/alkyl alcohols were prepared through hydrogenation, which can be used directly in organic synthesis.
引用
收藏
页码：4144 / 4147
页数：4
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