Kidney-limited thrombotic microangiopathy in patients with SLE treated with romiplostim

被引：11
|
作者：
Tomov, S. [1 ]
Lazarchick, J. [2 ]
Self, S. E. [2 ]
Bruner, E. T. [2 ]
Budisavljevic, M. N. [1 ,3 ]
机构：
[1] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA
[2] Pathol & Lab Med Med Univ South Carolina, Charleston, SC USA
[3] Ralph H Johnson VA Med Ctr, Charleston, SC USA
来源：
LUPUS | 2013年 / 22卷 / 05期
关键词：
Thrombotic microangiopathy; antiphospholipid syndrome; thrombotic thrombocytopenic purpura; romiplostim; acute renal failure; systemic lupus erythematosus; plasma exchange; SYSTEMIC-LUPUS-ERYTHEMATOSUS; THROMBOCYTOPENIC PURPURA; ANTIPHOSPHOLIPID SYNDROME; HEMOLYTIC-ANEMIA; VASCULAR-LESIONS; NEPHRITIS; THROMBOPOIETIN; ANTIBODIES;
D O I：
10.1177/0961203313477900
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We present the case of a 19 year-old Caucasian female with history of systemic lupus erythematosus (SLE) and normal baseline kidney function who developed severe acute renal failure following treatment of thrombocytopenia with the thrombopoietic agent romiplostim. Percutaneous kidney biopsy revealed thrombotic microangiopathy (TMA) without immune complex lupus glomerulonephritis. We discuss pathogenesis and differential diagnosis of TMA in patients with SLE and raise concerns regarding the use of thrombopoietic agents in such patients. Based on favorable long-term outcome in our case aggressive treatment and in particular prolonged use of plasma exchange in these patients are advocated. Lupus (2013) 22, 504-509.
引用
收藏
页码：504 / 509
页数：6
相关论文
共 50 条
  • [1] Kidney-limited thrombotic microangiopathy and eculizumab response
    Wetzels, Jack F.
    KIDNEY INTERNATIONAL, 2025, 107 (03) : 571 - 572
  • [2] Etiology and Outcomes of Kidney-Limited and Systemic Thrombotic Microangiopathy
    van Doorn, Daan P. C.
    Tobal, Rachid
    Abdul-Hamid, Myrurgia A.
    van Paassen, Pieter
    Timmermans, Sjoerd A. M. E. G.
    MODERN PATHOLOGY, 2025, 38 (04)
  • [3] Pegylated Liposomal Doxorubicin Causes Kidney-limited Thrombotic Microangiopathy
    Glezerman, Ilya
    Salvatore, Steven
    Tap, William
    Kelly, Ciara
    Ornelas, Claudia Michelle Brauer
    Shaikh, Aisha
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2024, 83 (04) : 549 - 553
  • [4] Pegylated Liposomal Doxorubicin and Kidney-Limited Thrombotic Microangiopathy in a Kidney Transplant Recipient: A Case Report
    Rodriguez-Ramirez, Sonia
    Yau, Kevin
    Kitchlu, Abhijat
    John, Rohan
    Rose, April A. N.
    Hogg, David
    Kim, S. Joseph
    KIDNEY MEDICINE, 2022, 4 (05)
  • [5] Kidney-Limited Thrombotic Microangiopathy (TMA) Is Prevalent along the Spectrum of TMA and Does Not Exclude Complement Defects
    van Doorn, Daan P. C.
    Timmermans, Sjoerd
    van Paassen, Pieter
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (10):
  • [6] Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies
    Maisons, Valentin
    Duval, Anna
    Mesnard, Laurent
    Frimat, Marie
    Fakhouri, Fadi
    Grange, Steven
    Servais, Aude
    Cartery, Claire
    Fauchier, Laurent
    Coppo, Paul
    Titeca-Beauport, Dimitri
    Fage, Nicolas
    Delmas, Yahsou
    Querard, Anne-Helene
    Seret, Guillaume
    Bobot, Mickael
    Le Quintrec, Moglie
    Ville, Simon
    von Tokarski, Florent
    Chauvet, Sophie
    Wynckel, Alain
    Martins, Manon
    Schurder, Juliet
    Barbet, Christelle
    Sautenet, Benedicte
    Gatault, Philippe
    Caillard, Sophie
    Vuiblet, Vincent
    Halimi, Jean-Michel
    KIDNEY INTERNATIONAL, 2024, 105 (05) : 1100 - 1112
  • [7] Kidney-limited TMA is common in patients with complement dysregulation
    van Doorn, Daan P. C.
    van Paassen, Pieter
    Timmermans, Sjoerd A. M. E. G.
    KIDNEY INTERNATIONAL, 2024, 106 (03) : 536 - 537
  • [8] FATAL THROMBOTIC MICROANGIOPATHY IN PATIENTS WITH SLE - A FULMINANT AND MISDIAGNOSED CONDITION
    WOOD, G
    PARFREY, NA
    CONNOLLY, CE
    GAFFNEY, EF
    HUTCHINS, GM
    LABORATORY INVESTIGATION, 1990, 62 (01) : A108 - A108
  • [9] Thrombotic Microangiopathy and the Kidney
    Dorman, A. M.
    JOURNAL OF PATHOLOGY, 2015, 237 : S10 - S10
  • [10] Thrombotic Microangiopathy and the Kidney
    Brocklebank, Vicky
    Wood, Katrina M.
    Kavanagh, David
    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2018, 13 (02): : 300 - 317
12345