Protein targeting with SAF(er) electrophiles

被引：3
|
作者：
Speltz, Thomas E. [1 ]
Moellering, Raymond E. [1 ]
机构：
[1] Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA
来源：
NATURE CHEMISTRY | 2020年 / 12卷 / 10期
关键词：
SUFEX;
D O I：
10.1038/s41557-020-00553-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrophilic groups that undergo sulfur-exchange chemistry with protein nucleophiles can serve as the functional basis of chemical proteomic probes. A new addition to this class, sulfuramidimidoyl fluoride (SAF), which can be included in an array of covalent small molecule probes, exhibits a unique reactivity profile with proteins.
引用
收藏
页码：885 / 887
页数：3
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