The role of the calcium-sensing receptor in epidermal differentiation

被引：94
|
作者：
Tu, CL [1 ]
Oda, Y
Komuves, L
Bikle, DD
机构：
[1] Univ Calif Irvine, Vet Affairs Med Ctr, Dept Med, San Francisco, CA 94121 USA
[2] Endocrine Unit, San Francisco, CA 94121 USA
来源：
CELL CALCIUM | 2004年 / 35卷 / 03期
关键词：
calcium-sensing receptor; epidermal differentiation; calcium;
D O I：
10.1016/j.ceca.2003.10.019
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Calcium regulates the proliferation and differentiation of keratinocytes both in vivo and in vitro. Elevated extracellular Ca2+ concentration ([Ca2+](o)) raises the intracellular free calcium ([Ca2+](i)) and activates differentiation-related genes. Cells lacking the calcium-sensing receptor (CaR) fail to respond to [Ca2+](o) and to differentiate, indicating a role for CaR in keratinocyte differentiation. These concepts derived from in vitro experiments have been tested and confirmed in two mouse models. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：265 / 273
页数：9
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