Plasma homocysteine levels are not increased in murine models of Alzheimer's disease

Alzheitner's disease (AD) patients tend to have increased plasma levels of homocysteine. However, it is unclear whether abnormality in hornocysteine levels is a primary cause of Alzheimer's disease or a disease marker. In order to investigate the relative impact of Alzheimer's disease on plasma homocysteine levels, total plasma homocysteine levels were evaluated in transgenic mouse models that exhibit abnormalities in their brains that are similar to Alzheimer's patients. No significant difference was observed in blood of marine models compared to control trice, indicating that elevated plasma hornocysteine level seems to be a risk marker at the most. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.