Polymer-mediated ternary supramolecular interactions for sensitive detection of peptides

被引：6
|
作者：
Serrano, Mahalia A. C. [1 ]
He, Huan [1 ]
Zhao, Bo [1 ]
Ramireddy, Rajasekhar R. [1 ]
Vachet, Richard W. [1 ]
Thayumanavan, S. [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
来源：
ANALYST | 2017年 / 142卷 / 01期
基金：
美国国家卫生研究院;
关键词：
DESORPTION/IONIZATION MASS-SPECTROMETRY; MALDI-MS; SIGNAL ENHANCEMENT; REVERSE MICELLES; SELECTIVE ENRICHMENT; PROTEINS; DERIVATIZATION; EXTRACTION; HOST;
D O I：
10.1039/c6an01591c
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A combination of donor-acceptor and electrostatic interactions in a three-component supramolecular system has been shown to form the basis for selective and sensitive detection of peptides. Different substituents in the polymer and the detection matrix were compared to demonstrate that the favorable donor-acceptor interactions explain the observed signal enhancement. The ternary supramolecular interactions discovered in this work are enabled by the self-packing behavior of amphiphilic homopolymers and their ability to mediate interactions between the detection matrix and peptide that facilitate sensitive detection of peptides.
引用
收藏
页码：118 / 122
页数：5
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