A General Organocatalytic Approach toward the Enantioselective Total Synthesis of Indolizidine Based Alkaloids

被引：33

作者：

Abels, Falko ^{[1
]}

Lindemann, Chris ^{[1
]}

Koch, Eva ^{[1
]}

Schneider, Christoph ^{[1
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 23期

关键词：

VINYLOGOUS MANNICH REACTION; ASYMMETRIC-SYNTHESIS; (-)-INDOLIZIDINE 167B;

D O I：

10.1021/ol302871u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four indolizidine based alkaloids (IBAs) have been synthesized in a highly enantioselective, straightforward, and flexible manner. As a key step our previously developed Bronsted acid catalyzed vinylogous Mannich reaction was employed which easily afforded gram amounts of an optically pure central intermediate which can be converted into a wide range of diversely substituted IBAs.

引用

页码：5972 / 5975

页数：4

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