Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants

被引：12
|
作者：
Maede, Yoshinobu [1 ]
Ibara, Satoshi [1 ]
Nagasaki, Hiraku [1 ]
Inoue, Takeshi [1 ]
Tokuhisa, Takuya [1 ]
Torikai, Motofumi [1 ]
Ishihara, Chie [1 ]
Matsui, Takako [1 ]
Kodaira, Yuichi [1 ]
机构：
[1] Kagoshima City Hosp, Dept Neonatol, Perinatal Med Ctr, Kagoshima 8928580, Japan
来源：
PEDIATRICS INTERNATIONAL | 2013年 / 55卷 / 06期
关键词：
extremely low-birthweight infants; fluconazole; fungal infections; micafungin; miconazole; prophylaxis; BIRTH-WEIGHT INFANTS; LIPOPEPTIDE ANTIFUNGAL AGENT; SYSTEMIC CANDIDIASIS; RISK-FACTORS; NEONATAL CANDIDIASIS; FK463; PHARMACOKINETICS; ASPERGILLOSIS; ECHINOCANDIN; EPIDEMIOLOGY;
D O I：
10.1111/ped.12157
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
BackgroundWe conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low-birthweight infants who were born at a gestational age of less than 26 weeks and weighed less than 1000g. MethodsWith a combination of enteral administration of miconazole (6mg/kg/day), FLCZ and MCFG were administered intravenously at a dose of 5mg/kg/day and 3mg/kg/day, respectively. The prophylaxis was classified as a failure when fungal infections were identified within the first 21 days after birth. ResultsThe prophylaxis was successful in seven of 18 cases (39%) in the FLCZ group and 15 of 21 cases (71%) in the MCFG group, indicating that the success rate was significantly higher in the latter group. ConclusionMCFG was superior to FLCZ as prophylaxis against fungal infections in extremely low-birthweight infants.
引用
收藏
页码：727 / 730
页数：4
相关论文
共 50 条
  • [1] Randomized Trial of Micafungin Versus Fluconazole in Prophylaxis Against Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients
    Park, Silvia
    Kim, Kihyun
    Jang, Jun Ho
    Kim, Seok Jin
    Kim, Won Seog
    Jung, Chul Won
    Jung, Ki Sun
    Cho, Jinhyun
    Yoo, Kwai Han
    Song, Haa-na
    [J]. BLOOD, 2015, 126 (23)
  • [2] Randomized trial of micafungin versus fluconazole as prophylaxis against invasive fungal infections in hematopoietic stem cell transplant recipients
    Park, Silvia
    Kim, Kihyun
    Jang, Jun Ho
    Kim, Seok Jin
    Kim, Won Seog
    Chung, Doo Ryeon
    Kang, Cheol-In
    Peck, Kyong Ran
    Jung, Chul Won
    [J]. JOURNAL OF INFECTION, 2016, 73 (05) : 496 - 505
  • [3] Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation
    van Burik, JAH
    Ratanatharathorn, V
    Stepan, DE
    Miller, CB
    Lipton, JH
    Vesole, DH
    Bunin, N
    Wall, DA
    Hiemenz, JW
    Satoi, Y
    Lee, JM
    Walsh, TJ
    [J]. CLINICAL INFECTIOUS DISEASES, 2004, 39 (10) : 1407 - 1416
  • [4] MICAFUNGIN VERSUS FLUCONAZOLE OR ITRACONAZOLE FOR PROPHYLAXIS AGAINST INVASIVE FUNGAL INFECTIONS DURING NEUTROPENIA IN PATIENTS UNDERGOING HAPLO-IDENTICAL HSCT
    Elcheikh, J.
    Crocchiolo, R.
    Furst, S.
    Bramanti, S.
    Sarina, B.
    Granata, A.
    Faucher, C.
    Mohty, B.
    Harbi, S.
    Bouabdallah, R.
    Vey, N.
    Chabannon, C.
    Santoro, A.
    Blaise, D.
    Castagna, L.
    [J]. BONE MARROW TRANSPLANTATION, 2014, 49 : S458 - S458
  • [5] Fluconazole prophylaxis against fungal infection in preterm infants
    Dani, C
    Bertini, G
    Pezzati, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (24): : 1913 - 1913
  • [6] Fluconazole prophylaxis against fungal colonization and infection in preterm infants
    Kaufman, D
    Boyle, R
    Hazen, KC
    Patrie, JT
    Robinson, M
    Donowitz, LG
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (23): : 1660 - 1666
  • [7] MICAFUNGIN VERSUS FLUCONAZOLE OR ITRACONAZOLE FOR PROPHYLAXIS AGAINST INVASIVE FUNGAL INFECTIONS DURING NEUTROPENIA IN PATIENTS UNDERGOING HAPLO-IDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION
    El Cheikh, J.
    Crocchiolo, R.
    Furst, S.
    Bramanti, S.
    Sarina, B.
    Granata, A.
    Faucher, C.
    Mohty, B.
    Harbi, S.
    Bouabdallah, R.
    Vey, N.
    Chabannon, C.
    Santoro, A.
    Blaise, D.
    Castagna, L.
    [J]. HAEMATOLOGICA, 2014, 99 : 163 - 163
  • [8] Prophylaxis with weekly versus daily fluconazole for fungal infections in patients with AIDS
    Havlir, DV
    Dubé, MP
    McCutchan, JA
    Forthal, DN
    Kemper, CA
    Dunne, MW
    Parenti, DM
    Kumar, PN
    White, AC
    Witt, MD
    Nightingale, SD
    Sepkowitz, KA
    MacGregor, RR
    Cheeseman, SH
    [J]. CLINICAL INFECTIOUS DISEASES, 1998, 27 (06) : 1369 - 1375
  • [9] Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants
    Autmizguine, Julie
    Smith, P. Brian
    Prather, Kristi
    Bendel, Catherine
    Natarajan, Girija
    Bidegain, Margarita
    Kaufman, David A.
    Burchfield, David J.
    Ross, Ashley S.
    Pandit, Paresh
    Schell, Wiley A.
    Gao, Jamie
    Benjamin, Daniel K., Jr.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 73 (12) : 3482 - 3487
  • [10] Cost-Effectiveness Analysis of Micafungin Versus Fluconazole for Prophylaxis of Invasive Fungal Infections in Patients Undergoing Hematopoietic Stem Cell Transplantation in Korea
    Sohn, Hyun Soon
    Lee, Tae-Jin
    Kim, Jinhyun
    Kim, Donghwan
    [J]. CLINICAL THERAPEUTICS, 2009, 31 (05) : 1105 - 1115
12345