Synthesis, crystal structure and biological evaluation of three new Rh(III) complexes incorporating benzimidazole derivatives

被引：6
|
作者：
Liu, Jun-Hong [1 ]
Pan, Feng-Hua [2 ]
Wang, Zhen-Feng [2 ]
Wang, Rong [2 ]
Yang, Lin [2 ]
Qin, Qi-Pin [2 ,3 ]
Tan, Ming-Xiong [2 ]
机构：
[1] Baotou Iron Steel Vocat Tech Coll, Baotou 014010, Inner Mongolia, Peoples R China
[2] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, 1303 Jiaoyudong Rd, Yulin 537000, Peoples R China
[3] Guangxi Normal Univ, Sch Chem & Pharm, State Key Lab Chem & Mol Engn Med Resources, 15 Yucai Rd, Guilin 541004, Peoples R China
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2020年 / 118卷
基金：
中国国家自然科学基金;
关键词：
Benzimidazole derivatives; Rh(III) complexes; Cell apoptosis; Mitochondrial dysfunction; TUMOR-CELL APOPTOSIS; G-QUADRUPLEX DNA; HIGH IN-VITRO; RUTHENIUM(II) COMPLEXES; MITOCHONDRIAL FUNCTIONS; IRIDIUM(III) COMPLEXES; RHODIUM(III) COMPLEX; TELOMERASE ACTIVITY; ANTITUMOR-ACTIVITY; MOLECULAR DOCKING;
D O I：
10.1016/j.inoche.2020.108017
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Three new non-cisplatin analogs [Rh(BID1)(CH3OH)]center dot CH3OH (Rh-1), [Rh(BID2)(CH3OH)]center dot CH3OH (Rh-2) and [Rh(BID3)(CH3OH)]center dot 2CH(3)OH (Rh-3) bearing benzimidazole derivatives (BID1-BID-3) were first prepared as potential anti-tumor compounds. The Rh-3 complex with 8-fluoro group in BID-3 ligand exhibited potential antiproliferative activity against multidrug-resistant human lung adenocarcinoma A549/DDP and cisplatin-resistant human ovarian cancer SK-OV-3/DDP cells, at most 5.0 fold more potent than Rh-1, Rh-2 and cisplatin under the same conditions. Importantly, Rh-1-Rh-3 are more selective for A549/DDP cells versus human normal liver HL-7702 cells. The Rh-2 and Rh-3 caused mitochondrial dysfunction was in the following order: Rh-3 > Rh-2. The different biological behavior of Rh-1-Rh-3 may correlate with different 8-substituted groups in benzimidazole derivatives.
引用
收藏
页数：4
相关论文
共 50 条
  • [1] SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW RH (I) COMPLEXES WITH SULFONAMIDE DERIVATIVES
    CRACIUNESCU, G
    SCARCIA, V
    FURLANI, A
    IGLESIAS, EP
    GHIRVU, C
    PAPAIOANNOU, A
    ANTICANCER RESEARCH, 1989, 9 (03) : 781 - 785
  • [2] Synthesis, crystal structure, and in vitro biological evaluation of bismuth (III) complexes incorporating pyrazinohydrazide-derived Schiff bases
    Li, Chuan-Hua
    Qiu, Ming-Hui
    Ma, Hui-Min
    Peng, Yan
    Ji, Chen
    Jiang, Jian-Hong
    Lan, Xiao-Bing
    Li, Xu
    Tao, Li-Ming
    APPLIED ORGANOMETALLIC CHEMISTRY, 2024, 38 (07)
  • [3] Synthesis of ruthenium(III) complexes with benzimidazole derivatives
    Vyas, PC
    Chahar, YK
    Garg, Y
    Seth, G
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2003, 80 (09) : 843 - 844
  • [4] New benzimidazole derivatives: Design, synthesis, docking, and biological evaluation
    Obaid, Rami J.
    ARABIAN JOURNAL OF CHEMISTRY, 2023, 16 (02)
  • [5] SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF BENZIMIDAZOLE DERIVATIVES
    Anand, Keshav
    Wakode, Sharad
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2018, 9 (02): : 617 - 624
  • [6] Design, synthesis, and characterization of some new benzimidazole derivatives and biological evaluation
    Bektas, Hakan
    Sokmen, Bahar B.
    Aydin, Sinem
    Mentese, Emre
    Bektas, Adile
    Dilekci, Gamze
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (05) : 2234 - 2242
  • [7] SYNTHESIS AND CHARACTERIZATION OF RUTHENIUM(III) COMPLEXES WITH BENZIMIDAZOLE DERIVATIVES
    VYAS, PC
    KAUR, N
    GOEL, AK
    VYAS, S
    ASIAN JOURNAL OF CHEMISTRY, 1995, 7 (04) : 873 - 876
  • [8] Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives
    Mariappan, G.
    Bhuyan, N. R.
    Kumar, Pradeep
    Kumar, Deepak
    Murali, K.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2011, 50 (09): : 1216 - 1219
  • [9] Synthesis, characterization and biological evaluation of novel benzimidazole derivatives
    Mahmood, Khalid
    Akhter, Zareen
    Asghar, Muhammad Adeel
    Mirza, Bushra
    Ismail, Hammad
    Liaqat, Faroha
    Kalsoom, Saima
    Ashraf, Ahmad Raza
    Shabbir, Muhammad
    Qayyum, Muhammad Abdul
    McKee, Vickie
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 38 (06): : 1670 - 1682
  • [10] Gold complexes with benzimidazole derivatives: synthesis, characterization and biological studies
    Vinicius Zamprogno Mota
    Gustavo Senra Gonçalves de Carvalho
    Adilson David da Silva
    Luiz Antônio Sodré Costa
    Patrícia de Almeida Machado
    Elaine Soares Coimbra
    Carmen Veríssima Ferreira
    Silvia Mika Shishido
    Alexandre Cuin
    BioMetals, 2014, 27 : 183 - 194
12345