The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: A meta-analysis

被引：57

作者：

Pei, Yu ^{[1
]}

Smith, Alicia K. ^{[2
]}

Wang, Yongjun ^{[1
]}

Pan, Yanli ^{[1
]}

Yang, Jian ^{[1
]}

Chen, Qi ^{[1
]}

Pan, Weigang ^{[1
]}

Bao, Feng ^{[1
]}

Zhao, Lisha ^{[1
]}

Tie, Changle ^{[1
]}

Wang, Yizheng ^{[3
]}

Wang, Jian ^{[1
]}

Zhen, Wenfeng ^{[1
]}

Zhou, Jinxia ^{[4
,5
]}

Ma, Xin ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Anding Hosp, Beijing 100088, Peoples R China

[2] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

[3] Capital Med Univ, Dept Neurobiol, Beijing 100088, Peoples R China

[4] Univ New S Wales, Sydney, NSW 2031, Australia

[5] Neurosci Res Australia, Sydney, NSW 2031, Australia

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2012年 / 159B卷 / 05期

基金：

中国国家自然科学基金;

关键词：

BDNF; Val66Met; geriatric; depression; meta-analysis; WHITE-MATTER HYPERINTENSITIES; ACTIVITY-DEPENDENT SECRETION; LATE-LIFE; MOOD DISORDERS; HIPPOCAMPAL VOLUME; ALZHEIMERS-DISEASE; HUMAN-MEMORY; GENOTYPE; EXTINCTION; BIPOLAR;

D O I：

10.1002/ajmg.b.32062

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. Genetic association studies of the BDNF Val66Met polymorphism (rs6265) in geriatric depression have produced inconsistent results. A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. A total of five studies involving 523 cases with geriatric depression and 1,220 psychiatrically healthy controls was included. Met allele carriers had an increased risk for geriatric depression when compared to Val/Val homozygotes (P?=?0.004, OR?=?1.48, 95% CI?=?1.131.93). Our findings suggest the BDNF Met allele may confer increased risk for depression as individual age. (C) 2012 Wiley Periodicals, Inc.

引用

页码：560 / 566

页数：7

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