The Allylic Alkylation of Ketone Enolates

被引：14
|
作者：
Junk, Lukas [1 ]
Kazmaier, Uli [1 ]
机构：
[1] Saarland Univ, Organ Chem 1, Campus C4-2, D-66123 Saarbrucken, Germany
来源：
CHEMISTRYOPEN | 2020年 / 9卷 / 09期
关键词：
allylic alkylations; enolates; ketones; palladium; transition metals; CATALYZED DECARBOXYLATIVE ALLYLATION; ENANTIOSELECTIVE TOTAL-SYNTHESIS; TRANSITION-METAL CATALYSIS; FORMAL SYNTHESIS; ASYMMETRIC ALKYLATION; CONJUGATE ADDITION; VINYLOGOUS ESTERS; ALPHA-ALLYLATION; INNER-SPHERE; PALLADIUM;
D O I：
10.1002/open.202000175
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The palladium-catalyzed allylic alkylation of non-stabilized ketone enolates was thought for a long time to be not as efficient as the analogous reactions of stabilized enolates, e. g. of malonates and beta-ketoesters. The field has experienced a rapid development during the last two decades, with a range of new, highly efficient protocols evolved. In this review, the early developments as well as current methods and applications of palladium-catalyzed ketone enolate allylations will be discussed.
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页码：929 / 952
页数：24
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