Discovery of HLA-DRB1*03:20 allele in a Taiwanese volunteer hematopoietic stem cell donor and the probable HLA-A, -B, -C and-DRB1 haplotype in association with DRB1*03:20

被引：0
|
作者：
Yang, K. L. [1 ,2 ,3 ,4 ]
Lee, S. K. [1 ,2 ,3 ]
Yang, S. Y. [1 ,2 ,3 ]
Kao, R. H. [1 ,2 ,3 ]
Lin, C. L. [1 ,2 ,3 ]
Lin, P. Y. [1 ,2 ,3 ]
机构：
[1] Buddhist Tzu Chi Gen Hosp, Buddhist Compass Relief Tzu Chi Fdn, Immunogenet Lab, Hualien 970, Taiwan
[2] Buddhist Tzu Chi Gen Hosp, Buddhist Compass Relief Tzu Chi Fdn, Buddhist Tzu Chi Stem Cells Ctr, Cord Blood Bank, Hualien 970, Taiwan
[3] Buddhist Tzu Chi Gen Hosp, Buddhist Compass Relief Tzu Chi Fdn, Marrow Donor Registry, Hualien 970, Taiwan
[4] Buddhist Tzu Chi Univ, Buddhist Compass Relief Tzu Chi Fdn, Dept Med Biotechnol, Hualien, Taiwan
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2013年 / 40卷 / 03期
关键词：
LEUKOCYTE ANTIGEN-A; MARROW DONOR; POPULATION; DIVERSITY; REGISTRY;
D O I：
10.1111/j.1744-313X.2012.01151.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The allele HLA-DRB1*03:20, a variant of DRB1*03, was first reported to the IMGT HLA database in April 2001 without indication on the ethnicity of the blood donor (Cell ID: HC 125775). We found a Taiwanese volunteer hematopoietic stem cell donor carries DRB1*03:20 by a sequence-based typing (SBT) method. The DNA sequence of DRB1*03:20 is identical to the sequence of DRB1*03:01:01 in exon 2, except a nucleotide substitution at position 341(TC) (GTTGCT at codon 85). The nucleotide replacement produced an amino acid variation at residue 85 (VA). We hypothesize that DRB1*03:20 was probably derived from DRB1*03:01:01 via a nucleotide point mutation event. The probable HLA haplotype in association with DRB1*03:20 was deduced as A*11:02-B*58:01-C*07:02-DRB1*03:20. We here report the Taiwanese/Chinese ethnicity of DRB1*03:20.
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收藏
页码：243 / 245
页数：3
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