Hyperlipidemia is a disease of fat metabolism or abnormal operation in healthcare, characterized by one or more of high total cholesterol (TC), high triglycerides (TG), high low-density lipoprotein cholesterol (LDL-C) and low high-density lipoprotein cholesterol (HDL-C) in blood. Hyperlipidemia is prone to cardiovascular and cerebrovascular diseases, obesity, diabetes, hyperinsulinemia and other diseases, posing a serious threat to human health. However, the commonly used chemical synthetic lipid-lowering drugs have obvious clinical effects, but the effect is biased to single and adverse reactions, such as adverse reactions of the nervous system, gastrointestinal reactions and liver damage. In recent years, a large number of literatures had reported that various medicinal plants or their active ingredients had lipid-lowering effects. Thus, finding safe and effective lipid-lowering components from natural medicines has a broad development prospects in research. In this review, I tried to explore the information of several active components of lipid-lowering plants and their lipid-lowering mechanisms, which may help future researchers develop new natural lipid-lowering drugs to treat hyperlipidemia.