HLA class I: friend and foe of multiple sclerosis

被引:5
|
作者
Martin, Roland [1 ]
机构
[1] Univ Med Ctr Eppendorf, Ctr Mol Neurobiol, Inst Neuroimmunol & Clin Multiple Sclerosis Res, D-20251 Hamburg, Germany
关键词
D O I
10.1038/nm1108-1150
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Findings in a mouse model of multiple sclerosis highlight the contribution of CD8(+) T cells, previously largely ignored in this disease. The work also helps answer why certain variants of the human leukocyte antigen (HLA) complex are protective, while others increase risk for disease (pages 1227-1235).
引用
收藏
页码:1150 / 1151
页数:3
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